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Studies have found that NNMT expression is significantly elevated in the fat tissue of obese individuals compared to lean controls

In pancreatic KRAS-mutated cancer cells, which can proliferate using albumin as the extracellular source of leucine, loss of SLC38A9 or its transport function strongly inhibited mTORC1 activation by macropinocytosed albumin as evidenced by cell proliferation and tumor formation (Goberdhan et al., 2016

Meanwhile, Asia Pacific is emerging as a high-growth region, particularly due to increasing diabetes burden in countries like China and India, improving healthcare infrastructure, and rising patient awareness

doi: 10.1167/iovs.02-0822 44 RoushdyE

Both backed by decades of published research