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7:1034-1043 (2022) Acknowledgements This study was financially supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) (RS-2025-02218354) and by the R&D Program of MOTIE/KEIT (RS-2025-02307907)
Meanwhile, NF1 is significantly co-mutated with KIT in 32% of MMs, whereas the co-occurrence level in CM is merely 4% (99), which indicates that the MAPK cascade is upregulated in MM not only by the single protein in the cytoplasm but also by the assistance of C-KIT receptor on the cell membrane
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Existing 1 H-MRS studies are small and show some conflicting results, with different studies focusing on different regions of the brain
However, this evidence tends to be: a) conflicting or inconclusive
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