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Univariable analysis testing for interaction In univariable analysis with GEE approach, including the interaction term (group*time effect), the difference in mean FTND scores when compared to the reference group was lower by 0.66 points in e-cigarette users (95% CI, 1.57 to 0.24) and by 1.02 points in combined cigarette users (95% CI, 2.31 to 0.26)

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People using nicotine pouches or snus in an attempt to cut back will also feel the same sensation, given that it provides the same 'rush' without the extra added smoke, tar or liquid

Briefly, we tested the assumption of equality of variances between the two regression trend lines using an F-test