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Limitations Not for visceral fat : Only works on subcutaneous fat (3-30mm thick)

Pharmacological interventions are more limited, with antidepressants such as duloxetine (a serotonin-noradrenaline reuptake inhibitor) or amitriptyline (a tricyclic antidepressant) sometimes considered

If pancreatitis is confirmed, the treatment should not be resumed, and GLP-1 RAs should not be started in patients with a history of pancreatitis [128]

When combined use with 5-FU, it increases the efficacy of chemotherapy in cancer, implying that microorganisms can be targeted to enhance chemotherapeutic efficacies (257)

Given the lifelong need for B12 therapy in deficiency-prone populations, the selection of the most patient-friendly and economically sustainable option is critical