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In the STEP 4 study, participants who stopped semaglutide gradually regained much of the weight, while those who continued maintained their loss

Although GLP-1RAs can attenuate inflammatory tone [105], sustained reductions in nutrient inflow associated with pharmacological weight loss may influence NAD turnover kinetics in metabolically stressed tissues

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The program includes comprehensive patient education about injection techniques, potential side effects, and lifestyle modifications that enhance medication effectiveness while supporting long-term weight maintenance