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mGPDH catalyzes the oxidation of G3P while reducing ubiquinone (CoQ 10 ) to ubiquinol (CoQ 10 H 2 ), thereby helping to sustain the mitochondrial CoQ 10 H 2 pool and suppress lipid peroxidation

Unlike MC4R-targeted agonists such as setmelanotide, whose efficacy is intrinsically limited by the functional status of the impaired receptor, GLP-1 RAs operate via pathways largely independent of the leptin-melanocortin circuitry

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