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High doses taken orally can build up waste products in the blood for those on dialysis

About 44% of users mentioned at least one issue, most often gastrointestinal problems

That group identified 25 patients with autism and either molecular or enzymatic evidence of a primary mitochondrial disorder, and all of the patients had met clinical criteria for probably or definite mitochondrial disease by the Modified Walker Criteria or the Mitochondrial Disease Criteria

doi:10.1210/edrv-17-2-121 Revelli A, Delle Piane L, Casano S, Molinari E, Massobrio M, Rinaudo P

In clinical studies, burping was reported as a side effect with most GLP-1 drugs: Ozempic (semaglutide) injecton: 3% of patients taking the 0.5 mg dose, and 1% of patients taking the 1 mg dose