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Notably, in the absence of semaglutide, the extent of atherosclerosis was not different in Glp1r Tie2/ versus Glp1r Tie2+/+ mice (Figure 2A)

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We induced a paw withdrawal response by applying an increasing force with a blunt-end metal filament (0.5 mm in diameter) at the center of the hindpaws plantar surface

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Its clinical use is currently limited to a single product, known as pramlintide, which is approved as an adjunct therapy in persons with insulin-treated diabetes

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