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It was the most effective antidiabetic agent anyone had ever seen, says Andrew Young, former vice president of research at Amylin Pharmaceuticals, the San Diegobased company that brought Byetta to market

Receptor sensitivity may be altered

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In sum, although DG-NR1KO mice showed a novelty-induced increase in Arc expressing granule cells, we detected impairments in three aspects: (1) overall reduction in Arc+ granule cells regardless of exposure to the novel environment or not

White C, Ji S, Cai H, et al (2012) Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders