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Moreover, recent studies have shown that TSH receptor activation in preadipocyte-derived fibroblasts can directly stimulate HA synthesis (112)

These effects were achieved under reduced activation of noncanonical signaling pathways including receptor internalization and -arrestin recruitment, an initially surprising observation as these have previously been linked to increased GLP-1R responses when measured acutely 10,14,36

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SoodSFeehanJItsiopoulosCWilsonKPlebanskiMScottDet al

7A), or (ii) two specific and independent SVCT4 duplication events at the base of the Actinopteri and Amphibia taxonomic groups that originated two distinct genes similar to SVCT4 (arbitrarily designated as SVCT5 and SVCT6 , respectively