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In patients taking GLP-1 RAs or similar weight loss medication, wrinkles become more prominent, and the skin starts to sag in areas such as the temples, cheeks, tear troughs, jawline, marionette lines, and nasolabial folds

The most common causes are dietary insufficiency (especially in vegans) and malabsorption (often due to pernicious anemia or GI disorders)

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DOI: 10.1016/bs.vh.2016.09.005