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High ROS levels generated via endogenous (mitochondria, endoplasmic reticulum [ER], and NOXs) and exogenous sources (radiation, drugs, foods, cigarette smoking, and pollution) induce oxidative stress that is harmful to the host 46,47

This creates two problems: You don't get the benefits of the glutathione you paid for

Kidney Disease Patients: High doses may strain kidney function

Recent comprehensive reviews published in Brain, Behavior, & Immunity - Health highlight that both Long COVID and ME/CFS share this underlying oxidative stress pathology, suggesting that multi-ingredient antioxidant therapies that support cellular defense mechanisms warrant serious clinical attention

J Intern Med 253:240243 McClain CJ, Price S, Barve S, Devalarja R, Shedlofsky S (1999) Acetaminophen hepatotoxicity: an update