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[9] [10] For patients with established cardiovascular disease, SGLT2 inhibitors are generally prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable

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While grain-free diets carry the most documented risk for taurine deficiency, taurine synthesis declines with age in all dogs, and the Columbia University study showed lifespan and cellular aging benefits from supplementation regardless of dietary taurine content

Adipose tissue is a significant source of inflammatory mediators, and substantial weight reduction typically leads to decreased systemic inflammation and altered fatty acid profiles