May Reduce Inflammation Preliminary studies suggest that NNMT inhibition may lower systemic inflammation markers , helping reduce the oxidative stress burden that accelerates aging and disease progression
mTOR is induced by Flt3 ligand (Flt3L) and is necessary for the Flt3L-driven development of DCs [100], and mTOR inhibits IL-1 production to impede DC maturation and the ability to stimulate effector T cell responses
Ultraweak photon emission (UPE) is closely linked to reactive oxygen species (ROS), with intensity variations reflecting various physiological and pathological states, such as stress (thermal, chemical, mechanical), mitochondrial function, cell cycle, etc., and UPE intensity correlates with neural activity, oxidative reactions, EEG activity, cerebral blood flow, energy metabolism, and glutamate release (Esmaeilpour et al., 2020
Metformin Common side effects of metformin include stomach upset, stomach pain, gas, bloating, nausea, and diarrhea affecting up to 30% of patients on immediate-release formulations
Nur E, Verwijs M, de Waart DR, Schnog JJ, Otten HM, Brandjes DP, Biemond BJ, Elferink RP, CURAMA Study Group (2011) Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes
