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Monitoring the efficacy of the prescribed semaglutide dosage and adjusting it accordingly is vital for achieving optimal outcomes

The authors conclude that GLP-1 functions as "a central node linking gut microbiota, metabolic homeostasis, tissue repair, and immune regulation," a framing that positions GLP-1 pathway intervention not as a metabolic adjunct but as a legitimate disease-modifying strategy across the spectrum of age-related musculoskeletal degeneration

The corresponding proportions were 80.0% for the first- or second-choice therapy and 31.8% for the third- or subsequent-choice therapy, respectively ( Figure 4B

Studies continue to accumulate evidence that correlate microbiome alterations with depression, promising microbiota-based approaches pending further validation