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Cross-talk between Proc Natl Acad Sci USA 2013;110:9066-71

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With a number of GLP-1 medications in Phase 2 trials, we believe that the winning formula to stand out in a crowded landscape will be to combine medication with advanced behavior change to drive differentiated outcomes, while proving it with Phase 4 studies

The model was applied to VPA-attributed effects using the maximum likelihood expectation maximization algorithm implemented in WinNonlin version 8.02 (Pharsight Corp., Mountain View, CA)