The hazard ratio was 4.28 (95% CI, 1.62-11.29
Role of GLP-1 in obesity GLP-1 reduces appetite and food intake through its actions in the CNS.212,260,261 By interacting with receptors in the hypothalamus, GLP-1 influences satiety and reduces the consumption of food in both animals and humans.262 It functions not only in peripheral tissues but also directly within the CNS, crossing the blood-brain barrier or being produced centrally to act on the brain.262,263 GLP-1 regulates energy balance and food intake by acting on specific brain regions, especially the hypothalamus, a key area responsible for hunger and fullness sensations.264,265,266 The hypothalamus contains various neurons that respond to different nutritional signals and hormones, like GLP-1, to regulate food intake.265,266 When GLP-1 binds to its receptors in the hypothalamus, it activates specific neurons, including those that promote satiety (POMC/CART neurons) and inhibits those that induce hunger (NPY/AgRP neurons), thereby enhancing the feeling of fullness and reducing food intake.233,267 GLP-1 can slow down gastric emptying through its effects on smooth muscles and the nervous system in the gastrointestinal tract.264,268 Released at the guts end, GLP-1 acts on its receptors in the gastrointestinal tract, leading to reduced gastric muscle contractions and extended food retention in the stomach.264,269 Furthermore, GLP-1 can slow down gastric emptying by activating the vagus nerve, a part of the autonomic nervous system crucial for regulating the activities of the gastrointestinal tract.268 When activated, the vagus nerve can reduce the contraction of the stomach, thereby slowing down food emptying.269 The prolonged retention of food in the stomach enhances the feeling of fullness, naturally reducing overall food intake.270,271 Additionally, slower gastric emptying helps stabilize postprandial blood glucose levels
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BenchenaneKBerezowskiVAliCFernndez-MonrealMLpez-AtalayaJPBrillaultJet alTissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptorrelated protein-mediated transcytosis
