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If these clearing and balancing processes aren't working properly, certain bacteria and archaea can multiply excessively, leading to an overgrowth

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The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39

The mechanism by which it does this is not fully understood [110], though proposed mechanisms include: (1) antagonism of the persistent sodium (Na+) current, thereby reducing hyperexcitability

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