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Adverse events with oral GLP-1 RA Similar to injectable GLP-1 RA, the most common AE with oral GLP-1 RA were gastrointestinal which were mild to moderate in severity (Tables 2 and 3, safety outcomes)

Research protocols for DSIP typically range from 25g to 500g per injection, depending on the endpoint being measured (sleep architecture, cortisol modulation, stress response)

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Beyond validating a novel long-acting strategy, TransCon also highlights the increasingly important role of PEG carriers and linker technologies in enabling controlled and sustained drug release