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Substantial or rapid reduction in body weight can alter the hypothalamic-pituitary-ovarian (HPO) axis, leading to changes in oestrogen and progesterone levels

[DOI] [PubMed] [Google Scholar] 5.Allen LH, Rosado JL, Casterline JE, Lopez P, Muoz E, Garcia OP, Martinez H

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It introduces foam, increases shear stress, and makes a borderline reconstitution worse