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They were also more likely to have their gallbladders removed and experience drug-induced pancreatitis

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Clinical trials have demonstrated that tirzepatide produces substantial weight loss, with patients without diabetes achieving approximately 15-20% body weight reduction at the highest doses in the SURMOUNT trialssignificantly greater than results observed with selective GLP-1 receptor agonists

The most common side effects are gastrointestinal, including nausea (12-24% of patients), diarrhea (12-17%), decreased appetite (10-14%), vomiting (6-12%), and constipation (11-17%)