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TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation

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ACPA occurs as a result of an abnormal antibody response to a range of citrullinated proteins, including fibrin, vimentin, fibronectin, Epstein-Barr Nuclear Antigen 1 (EBNA-1), -enolase, type II collagen, and histones, all of which are distributed throughout the whole body