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As the brain does not reach full development until the age of 25 years, nicotine use by those aged 1824 years continues to make detrimental changes to their brain functionality, contributing to addiction susceptibility 1,6

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Though some preclinical studies showed inhalation of PG and glycerol can be safe up to 28 days (Werley et al., 2011) or 18 months (Robertson et al., 1947), breathing aerosolized PG can also affect the risk of asthma development (Choi et al., 2010)

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