[DOI] [Google Scholar] 109.Ivezaj V., Grilo C.M
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Hepatic synthesis of glutathione and nutritional substrates, co-factors, and other nutrients that influence metabolism 5-Methyl-tetrahydrofolate (5MTHF), system alanineserinecysteine (ASC), cystathionine--synthase (CBS), cystathionine gamma-lyase (CGL), electrophile response element (EpRE), glutathione-S-transferase (GST), glutamate cysteine ligase (GCL), glutathione reductase (GRx), glutathione peroxidase (GPx), glutathione synthetase (GSx), hydrogen peroxide (H 2 O 2 ), Nuclear factor erythroid factor-2-related factor 2 (Nrf2), S-adenosylmethionine (SAMe), S-adenosylhomocysteine (SAH), tetrahydrofolate (THF), thioredoxin reductase 1 (TRR1), water (H 2 O), cystine/glutamate antiporter system (x c )
The observed reduction in legal blindness among GLP-1 RA users may be attributed to the drug classs systemic vascular and metabolic benefits, which could mitigate several sight-threatening complications of diabetes
Influencing factor #2: The tolerability/safety of GLP-1s Why it matters : Even if GLP-1s prove to be highly effective, lack of tolerability or the presence of uncomfortableor even dangerousside effects, could make it difficult for patients to actually take these medications
