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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression

Reported oral tolerance is generally acceptable in small studies, but gastrointestinal discomfort or source-related allergy concerns may occur

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Of course, if youre under 200, you wouldnt really need to do that

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