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Behavioral support becomes important because many habits remain deeply ingrained through repetition and emotional association and they continue to fire at familiar trigger moments regardless of nicotine levels

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If a company can demonstrate to the FDA that a specific product meets the applicable standard set forth by Congress, including considering how the marketing of the product may affect youth initiation and use, then the FDA could authorize that product for sale. Coupled with the recently signed legislation increasing the minimum age of sale of tobacco to 21, we believe this policy balances the urgency with which we must address the public health threat of youth use of e-cigarette products with the potential role that e-cigarettes may play in helping adult smokers transition completely away from combustible tobacco to a potentially less risky form of nicotine delivery, FDA Commissioner Stephen Hahn, MD, said in a statement

[37, 38] found that an acrolein concentration in the lung of an e-cigarette user is 16-fold higher than that in the breathing air recommended World Health Organization (WHO) threshold and 320-fold higher than the US Environmental Protection Agency (EPA) threshold