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To reduce the effect of bias, we adjusted observations that were generated in subpopulations, because it was the only significant bias covariate identified by the bias covariate selection algorithm (Supplementary Table 7)

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To use flake tobacco for rolling, you have options: Rub it out: Break the flake apart completely into loose strands Fold and stuff: Fold the flake and tear it into chunks (works better for pipes than cigarettes) Cube cut: Slice the flake into small cubes with scissors For rolling cigarettes, the rub-out method works best