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These associations, or conditioned responses, create powerful triggers that can prompt nicotine use even after a period of abstinence

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The researchers wrote that while it wasn't clear whether the same relationship would apply to regions of the genome that code for proteins, "our data suggest that paternal exposure to second-hand smoke may have reproductive consequences that go beyond the passive smoker." Marchetti said that the findings provided "compelling evidence in support of the argument that passive smoking should be regarded as a germ cell mutagen in humans"