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Heavy cannabis use is typically defined as smoking 2 or more joints per day, or using cannabis daily or near-daily

Public Act 095-0017) is a comprehensive tobacco control law that took effect in Illinois on January 1, 2008, banning smoking in virtually all buildings and transportation used by the general public, owned by the government or public body, or used as a place of employment

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Toxicol Sci 167(1):293304 Slotkin TA, Skavicus S, Card J, Stadler A, Levin ED, Seidler FJ (2015) Developmental neurotoxicity of tobacco smoke directed toward cholinergic and serotonergic systems: More than just nicotine

However, it has been reported that disproportionate production and neutralization of ROS affects sperm maturation (Takeshima et al., 2021)