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In platinum-resistant disease, lactate accumulation is accompanied by GCN5-dependent H3K9la and RAD51 K73 lactylation, which upregulate RAD51/BRCA2, strengthen homologous recombination repair, and reduce cisplatin sensitivity

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PCSK1/3 and PCSK2, PPCs subtypes in humans, perform the proteolytic cleavage of prohormones to their intermediate forms ( Brain and intestine GCG + cells are discovered to express PCSK1/3 while PCSK2 is expressed in the pancreas ( Figure 1 In 1966, Hopsu-Havu and Glenner discovered the existence of the enzyme dipeptidyl peptidase-4 (DPP-4) ( DPP4 gene