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Moreover, our data show that similar mitochondrial changes are present in bronchial epithelium from severe ex-smoking COPD patients in comparison to healthy controls, with depletion of cristae, increased branching, elongation and swelling of the mitochondria, increased Mn-SOD, PINK1 and PPARGC1, but not OPA1 mRNA expression and increased OXPHOS Complex VF1 levels

The researchers tried to disentangle the effect of smoking and disordered microbiota by exposing mice to cigarette smoke, then cohousing mice exposed to cigarette smoke and air-exposed mice (control) with germ-free mice

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