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In addition, exposure to tobacco smoke extract (TSE) exposure can cause human macrophages to release EVs (including exosomes and ectosomes), which contribute to the release of matrix metalloproteinase 14 (MMP14) and may contribute to emphysema [102, 103]

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S2) further confirmed that, compared with the baseline of control cells, AZI slightly increased the expression of Nrf2, E-cadherin and ZO-1, but the increased value was not statistically different