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Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not

The reassuring part: these events are overwhelmingly non-serious (99.5%) and mild to moderate (98.1%) in the obesity trials, and they are transient, clustering during dose escalation and easing with time

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What antihistamines DON'T do: They don't reduce mast cell activation or degranulation They don't decrease the amount of histamine being released They don't support the enzymes that break down histamine They don't address any of the other mediators released by mast cells (leukotrienes, prostaglandins, cytokines, tryptase) This is why symptoms come roaring back the moment your antihistamine wears off all that histamine is still there, along with everything else