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While these bacterial enzymes have been explored for the generation of natural product analogs or applications in biocatalysis, the broad utility of amide bond-forming enzymes in enzymatic combinatorial synthesis has not been fully realized because of unwanted cross-reactivities of the enzymes toward substrates and/or difficulties in finding partnering enzymes with comparable substrate promiscuity 56
If it weakens, relaxes at the wrong times, or doesnt stay closed, stomach acid can move up into the esophagus
R.et al (2005)
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10.1002/ijc.28641 49 WulaningsihW.HolmbergL.GarmoH.MalmstromH.LambeM.HammarN.et al (2015)
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