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The World Health Organization (WHO) still refuses to acknowledge its value, despite the fact that harm reduction is explicitly recognized in the Framework Convention for Tobacco Control.

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According to the Journal of the American Medical Association (JAMA), of the adults younger than 25 years who reported current e-cigarette use, 72 percent had never even smoked a combustible cigarette

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In their analysis, the study authors raised the need for direct comparisons focusing on the harm and tolerability of the four most effective treatment options e-cigarettes, varenicline, bupropion and combination NRT to aid clinical decision-making