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Natural products represent invaluable contributions to human health due to their potent medicinal properties and minimal side effects, making them increasingly favoured by the scientific community

Basal-like breast cancer (BLBC) accounts for 7080% of TNBC cases (25,26)

In clinical, a prolonged survival by metformin was only observed in diabetic PDA patients and no effect was found in the whole PDA population, which indicates the major effect of metformin is decreasing insulin resistance rather than anticancer effect ( (3)

Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-b-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice

doi: 10.1016/j.cyto.2003.08.013