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doi:10.1016/j.ymgme.2009.04.005
A number of studies have indicated the existence of a nuclear GSH pool that resists depletion after exposure of cells to BSO (for a review see [42]
They act in synergy and trigger degradation of the basement membrane and extracellular matrix components, destabilizing the vasculature and promoting migration and proliferation of endothelial cells
In the case of suspected cobalt hypersensitivity, an intradermal test dose should be administered because anaphylactic shock and death have followed parenteral administration of cyanocobalamin.
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