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Manish Sahni, MD, at Centra Internal Medicine The FDA clearance of oral semaglutide introduces the first pill-based GLP-1 option for weight loss, offering patients an alternative to injectable treatments

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B2 cells that participate in the immune system are pro-inflammatory factors that can promote NASH-associated liver fibrosis ( H 2 and T H 17 cells have a pro-fibrogenic impact ( H 17 can stimulate the formation of transforming growth factor- (TGF-), which promotes fibrosis by activating fibroblasts ( + PD1 + T cells in mice and humans with NASH ( + T cells attract HSCs with high expression of CCR5 and lead them to apoptosis via the FasL-Fas pathway, which results in the resolution of liver fibrosis ( 3.2 The abnormal lipid metabolism and lipid accumulation cause steatosis and lead to inflammation and MASLD Abnormal lipid metabolism is a crucial cause of MASLD

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No new drug applications (NDAs) or biologics license applications (BLAs) were approved by February 2026, based on FDA.gov searches [11]