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Conversely to the use of inhibitors, due to the interest in promoting maintenance of NAD + levels in aging and age-associated conditions, the development of NAMPT activators has been the emphasis of recent investigation

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4,5 Deficient GSH synthesis has been associated with oxidative stress in aging, 6 and GSH concentrations decrease with age, a factor thought to explain, in part, why the elderly are at greater risk of neurodegenerative diseases