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The EU, on the other hand, has a limit of 20 mg/mL for nicotine concentrations which is in comparison with a normal smoking cigarette

Significant activation of -opioid receptor-mediated neurotransmission from denicotinized to average nicotine conditions was observed in the right anterior cingulate cortex

This highlights the importance of replicating these studies in both studies using human tissue (where possible) and clinical trials, as the mechanisms driving acute and/or chronic cough may be different

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