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If the rash clearly tracks with poor injection technique, improving technique and recording changes often resolves the issue without stopping therapy

(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug

Starting at a low dose and gradually increasing, as the dosing schedule is designed to do, may help manage these effects

FDA-approved medications go through rigorous clinical trials involving thousands of patients, with data reviewed by independent experts

This is also when 73% of discontinuations happen