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Rubbing the spot can cause local irritation and may affect absorption

Nat Med 28(1):8995

Much like statins reshaped cardiovascular medicine, I suspect well look back on GLP-1s as the beginning of a new era in preventive and cognitive medicine. As a result, their reach has widened far beyond the diabetic and obese populations to a much broader segment of adults seeking sustainable metabolic and longevity health including early adopters experimenting with microdosing protocols for appetite control and energy regulation

Intestinal FXR mediates the hepatic T3 action on GLP-1 and glucose homeostasis To test whether intestinal FXR signaling was essential for the T3 action observed in this study, intestine-specific FXR-null mice (IFXRKO) were employed 31

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