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not primarily appetite-driven (OUP Academic) Expected weight loss (this is where many people get misled) In major obesity trials: Semaglutide 2.4 mg weekly: ~14.9% mean weight loss at 68 weeks (STEP-1) (PubMed) Tirzepatide: ~15.0% to ~20.9% mean weight loss at 72 weeks , dose-dependent (SURMOUNT-1) (PubMed) AOD-9604s best-known human signal is kilograms, not double-digit percentages , and later studies did not sustain a strong obesity-drug profile

May Reduce Inflammation Preliminary studies suggest that NNMT inhibition may lower systemic inflammation markers , helping reduce the oxidative stress burden that accelerates aging and disease progression

So, it may play a role in conditions such as Alzheimer's disease and stroke

These products include: Retatrutide Reta R-10, R-20 Investigations are ongoing