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McAdam, [email protected] This article was submitted to Analytical Chemistry, a section of the journal Frontiers in Chemistry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

As an alternate means to address the issue of multicollinearity between age at initiation and total PY, we also defined a new exposure variable, total PY divided by age at initiation, and categorized smokers into quartiles for an additional analysis