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In addition, criticisms about the translation of these results into clinical practice have been raised, for instance because of differences in the physiology and breathing behaviors between humans and rodents as well as the use of non-physiological exposure methods such as whole body exposure instead of mouth breathing [7, 18]

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In late 2018, the FDA issued warning letters to JUUL Labs and several other e-cigarette manufacturers stating that they were not doing enough to address the youth vaping epidemic

In conclusion, cigarette smoking poses a significant threat to public health, particularly among the youth in the Philippines