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The trend-level negative association between urinary cotinine and WB SUV is consistent with much prior research demonstrating that cotinine reduces neuroinflammation [75, 76]

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And thats creating a confusing picture for researchers: A 2018 report from the National Academy of Sciences that attempted to synthesize all of the studies available up to that time stated there was moderate evidence that e-cigarettes were effective as a smoking cessation tool but noted there was a discrepancy between randomized trials where the effect was evident, and observational surveys where it was not

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