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[DOI] [PubMed] [Google Scholar] 108.Townsend DM, Tew KD

[Expert commentary

Its findings, published recently in the American Journal of Ophthalmology , revealed a notable correlation between semaglutide, the most commonly prescribed GLP-1 RA, and increased incidents of ischemic optic neuropathy, diabetic retinopathy and several other retinal and vitreous issues

It is known that, in rat and human GLCL holoenzyme, cystamine completely inactivates rat GLCL activity by interaction with a thiol group that is thought to be at or near the l-glutamate-binding site in the wild enzyme [135,136,137,138] and also in a recombinant mutant (hGLCLC-C553G) where one cysteine group far from the active site was selectively inactivated [139]

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