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It is estimated that reproductive disorders account for about 23% of all cases of male infertility while the remaining percentage is due to environmental pollutants/toxicants (12)

Among them, drugs need to overcome the first pass effect of the liver and the blood-ocular barrier to reach the eye, so their bioavailability is relatively low

Poloxamer transforms into a gel at body temperature, increasing the drug retention time and absorption efficiency in the nasal cavity

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Tones and refines appearance of pores