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One limitation of this study is that experiments were conducted only in male animals, and it is possible that the findings may differ in females
Wild species used include Nicotiana attenuata in California, the Southwest, Northwest and adjacent Canada, various subspecies of Nicotiana quadrivalvis from the west coast and upper Missouri, Nicotiana glauca and trigonophylla from the Southwest, California, and Mexico
About 37% of patients who persist in smoking after apparent cure of their cancer will develop second cancers of the mouth, lips, tongue, and throat compared with only 6% of those who stop smoking
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