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2.1 Trimethylamine-N-oxide and betaine in humans In humans, TMAO is mostly biosynthesized from the unabsorbed dietary constituents containing trimethylamine moiety such as choline (concentrated in egg yolk and liver) and L-carnitine (predominantly in red meat) through the activity of inhabitant bacteria of the human large intestine (Li et al., 2018a) (Figure 2)

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In addition, our differential expression analysis identified upregulation of a considerable number of transcripts related to ribosomal proteins in Gclc fl/fl MZB compared to Gclc fl/fl FoB (Supplementary Fig

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